ABSTRACT
Background: Laparoscopic cholecystectomy is the gold standard treatment for symptomatic cholelithiasis and has multiple advantages over open approach. With increasing skills and techniques over the years, the contra-indications to laparoscopic cholecystectomy have reduced. Even after careful selection of appropriate candidates for laparoscopic cholecystectomy, it sometimes becomes necessary to convert into an open cholecystectomy to prevent complications. This study was undertaken so as to identify the intra-operative factors necessitating conversion of laparoscopic cholecystectomy to open cholecystectomy.Methods: In this study conducted at S. P. Medical College and P. B. M. Hospital, Bikaner, over a period of 1 year, 100 consecutive patients with symptomatic cholelithiasis, planned for laparoscopic cholecystectomy were included. Laparoscopic cholecystectomy was performed and cases which could not be completed laparoscopically were converted to open cholecystectomy via right subcostal incision. Intra-operative factors necessitating conversion were observed and analyzed.Results: The incidence of conversion was found to be 7%. The most common intra-operative factor for conversion was dense adhesions at the Calot’s triangle (71.43%) followed by obscure anatomy (42.86%). Uncontrolled bleeding and CBD stones also led to conversion. The identification and appearance of CBD and achievement of critical view of safety were significant factors for conversion to open cholecystectomy (p=0.0001).Conclusions: The rate of conversion to open cholecystectomy was 7% which is comparable to similar studies. Conversion is not a failure or complication but actually a safer alternative to ensure completion of the procedure without any real complications of laparoscopic cholecystectomy- biliary or visceral injury, haemorrhage, etc.
ABSTRACT
Background: GTAT 3 is a transcription marker for many tumors including breast tumors. Its play an important role in proliferation and differentiation of cell. Aim: The aim of the present study for assessment GATA 3 expression in Iraqi women with breast tumors and its association with histological grades and pathological stages. Materials and Methods: A retrospective study of 72 FFPET of breast tumors, 57/72 were primary breast malignant tumors (infiltrative ductal carcinoma IDC and infiltrative lobular carcinoma ILC), and 15/72 were benign breast tumors. Results: The nuclear staining of (1% or more) of tumor cells was considered positive expression for GATA 3 (cut off value 1%), 47 of 57 (82.5%) of malignant tumors were positive expression of GATA 3, while 3 of 15 (20.0%) of benign tumors were negative expression, (P 0.05). Conclusion: GATA 3 is a specific markers for breast carcinoma and its can be used for diagnosis of the malignant from benign tumors and it's considered a good prognosis marker for breast cancer.
ABSTRACT
Objective: To focus on the analysis of chemical constituents of the Thymus vulgaris L. (locally known as Zaitra or Za'atar; Family: Lamiaceae) which is available in the market of Saudi Arabia. Methods: The Zaitra oil was analyzed by gas chromatography-mass spectrometry. The mass spectra were compared with the standard spectra available in National Institute Standard and Technique library. Results: The results indicated that the Thymus oil is composed of many chemical compounds including a pinene, thymol and caryophyllene which are biologically active and also used in various diseases. Conclusions: It can be concluded that the Thymus vulgaris due to presence of many bioactive compounds can be used as a new potential source of medicine for the treatment of various types of illness.